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Søren Hough

Cancer Biologist, Journalist, and Science Writer

London, UK

Søren Hough

Cancer Biologist. Science Writer. Freelance journalist/editor. Founder/Editor-in-Chief at Movie Fail. Published at RogerEbert.com.

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Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis

Oncogenic KRAS underlies 30–90% of lung, colon, and pancreatic cancers, but despite more than 30 y of research, clinical inhibitors of KRAS—and potential resistance mechanisms—remain elusive. Using CRISPR-mediated genome editing of oncogenic Kras, we show that some lung cancer cells can survive Kras knockout, indicating the existence of mechanisms that allow tumors to escape Kras oncogene addiction.
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Guide Picker is a comprehensive design tool for visualizing and selecting guides for CRISPR experiments

Guide Picker (https://www.deskgen.com/guide-picker/) serves as a meta tool for designing CRISPR experiments by presenting ten different guide RNA scoring functions in one simple graphical interface. It allows investigators to simultaneously visualize and sort through every guide targeting the protein-coding regions of any mouse or human gene.
BMC Bioinformatics Link to Story
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Genome-wide CRISPR Screen Identifies Regulators of MAPK as Suppressors of Liver Tumors in Mice

It has been a challenge to identify liver tumor suppressors or oncogenes due to the genetic heterogeneity of these tumors. We performed a genome-wide screen to identify suppressors of liver tumor formation in mice, using CRISPR-mediated genome editing.
Gastroenterology Link to Story
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Desktop Genetics

Desktop Genetics is a bioinformatics company building a gene-editing platform for personalized medicine. The company works with scientists around the world to design and execute state-of-the-art clustered regularly interspaced short palindromic repeats (CRISPR) experiments.
Personalized Medicine Link to Story
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Seymour, Lloyd Garrison

Lloyd Garrison Seymour was a civil war soldier, Republican activist, and estate owner who lived during the 19th century in Hartford, Connecticut. My article on Lloyd Garrison Seymour was accepted by the "African American National Biography, a joint project of the W. E. B. Du Bois Institute for African and African American Research at Harvard University and Oxford University Press." ~ from the W. E. B. Dubois Institute at Harvard University website.
Oxford/Harvard University Press Link to Story
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Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses

Our findings provide a strategy to model human liver diseases in mice and highlight the importance considering Cas9-specific immune responses in future translational studies involving in vivo delivery of CRISPR/Cas9.
Human Gene Therapy Link to Story
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Eisenstein Goes Plane Crazy

For this essay, my professor asked us to find discuss an animated Disney short film through the lens of Soviet filmmaker Sergei Eisenstein. Quotes in this piece are taken from the translated compilation of Eisenstein’s notes in Jay Leda’s 1988 book, Eisenstein on Disney. Sergei Eisenstein, a Marxist filmmaker and theorist, had a unique relationship with the animated work coming out of Walt Disney Studios.
Movie Fail Link to Story
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Dimensionality Evokes the Perception of Life in Persepolis

For this essay, my professor asked us to analyze how a given animated film uses dimensionality to formally and technologically give the movie a sense of life. I chose write about Vincent Paronnaud and Marjane Satrapi’s film Persepolis through Thomas Lamarre’s theories of animation as outlined in his book, The Anime Machine.
Movie Fail Link to Story
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The Freedom of Movement in Chris Marker’s La Jetée

Movies as we know them today are a trick. They do not technically depict motion, but rather a series individual images shown in succession. Chris Marker evokes this idea as he tells the story of La Jetée (1962) through a series of still frames. By almost entirely removing motion from his film, Marker challenges the idea that cinema is solely the domain of the moving image as he weaves together an intricate portrait of memory, time and space.
Movie Fail Link to Story
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Robert Rodriguez’s Sin City Blurs Media, Genre, and Style

For this essay, my professor asked us to find a film and talk about how it uses elements from different media, genres, and styles to create something entirely new. I chose to talk about Robert Rodr...
Movie Fail Link to Story
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Discontinuity Editing Elicits Emotion in Eisenstein’s Strike

An academic paper I wrote on how early Soviet director Sergei Eisenstein uses discontinuous editing in his film Strike to encourage his audience to empathize with his protagonists. Strike is a piec...
Movie Fail Link to Story

About

Søren Hough

I currently work as the head science writer at Desktop Genetics where I cover advances and applications of CRISPR technology (https://www.deskgen.com/landing/resources).

I am also a freelance entertainment journalist. My work has been featured on key industry-centric websites including RogerEbert.com (www.rogerebert.com/interviews/the-magic-of-magi-douglas-trumbulls-quest-to-explore-a-new-planet-of-cinematic-potential) and ScottFeinberg.com (http://scottfeinberg.com/author/soren-hough).

I brought my experience as an editor and writer to The Massachusetts Daily Collegian (http://dailycollegian.com/author/soren-hough) one year later as I began working for the paper as a film and science correspondent. In the spring of 2013, I was hired as the editor of the film section of the paper for the fall of 2013.

I also started Movie Fail (http://moviefail.com) in January 2012, a site dedicated to multimedia reviews, op-eds, academic essays, and news articles about movies and the film industry.

In December 2013, I graduated from the Interdepartmental Program in Film Studies and Microbiology program at the University of Massachusetts Amherst.

The cover photo is a screen shot from Tete's short film, raintown.

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moviefail.com

Skills

  • Film Journalism
  • Film Critique
  • Blogging
  • Editing
  • Final Cut Pro
  • Microbiology Research
  • Epigenetics Research
  • Molecular Biophysics Research
  • Social Media
  • Radio
  • Content Management
  • CRISPR