Søren Hough

Cancer Biologist, Journalist, and Science Writer

London, UK

Søren Hough

Cancer Biologist. Science Writer. Freelance journalist/editor. Founder/Editor-in-Chief at Movie Fail. Published at


Interview with Nora Twomey, Director of The Breadwinner

Cartoon Saloon has knocked it out of the park ever since they hit the scene in 2009 with The Secret of Kells. Their feature-length movies have consistently garnered praise from critics. Nora Twomey, who co-directed Kells, is back as a solo director on the studio’s third film: The Breadwinner. The Breadwinner is an adaptation of Deborah Ellis’s book of the same name.
Movie fail Link to Story

Strategies for Improving CRISPR Specificity

Modifying nucleases and guide RNAs may reduce the off-target effect. Link to Story

Expanding Genome Editing Beyond Traditional CRISPR Nucleases

How Cas9 orthologs and other nucleases open new doors for basic and translational research. Link to Story

CRISPR Base Editing for Precise Genome Edits

Base editing precisely substitutes nucleotides and introduces point mutations for validation of clinically-relevant variants, and on a large scale, allows for the design of forward screens. Link to Story

London Film Festival 2017 Highlights

The London Film Festival sprawls across the city, from the café-laden streets of Shoreditch to the glamour of Southbank, by the Thames. Cult cinemas like the Prince Charles and megaplexes like the Odeon off Leicester Square premiere films from around the world. This year, festival darlings like Sally Potter (“The Party”) and Azazel Jacobs (“The Lovers”) found themselves front and center against a backdrop of drama, comedy and experimental art. Link to Story

The Future of CRISPR Applications in the Lab, the Clinic and Society.

CRISPR (clustered regularly interspaced short palindromic repeats) has emerged as one of the premiere biological tools of the century. Even more so than older genome editing techniques such as TALENs and ZFNs, CRISPR provides speed and ease-of-use heretofore unheard of in agriculture, the environment and human health.
Advances in Experimental Medicine and Biology, Springer Link to Story

Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis

Oncogenic KRAS underlies 30–90% of lung, colon, and pancreatic cancers, but despite more than 30 y of research, clinical inhibitors of KRAS—and potential resistance mechanisms—remain elusive. Using CRISPR-mediated genome editing of oncogenic Kras, we show that some lung cancer cells can survive Kras knockout, indicating the existence of mechanisms that allow tumors to escape Kras oncogene addiction.

Cell-Based Therapy for Disease Using CRISPR

CRISPR has accelerated basic research and therapeutic development. Its modular nature means it can be adapted to study and potentially treat nearly any genetic disease, including major killers like cancer and sickle cell anemia. The potential for CRISPR to transform medicine with highly precise, potentially one-off treatment options has given hope to those suffering from chronic and debilitating illness. Link to Story

Guide Picker is a comprehensive design tool for visualizing and selecting guides for CRISPR experiments

Guide Picker ( serves as a meta tool for designing CRISPR experiments by presenting ten different guide RNA scoring functions in one simple graphical interface. It allows investigators to simultaneously visualize and sort through every guide targeting the protein-coding regions of any mouse or human gene.
BMC Bioinformatics Link to Story

How Disney's "Mulan" Brazenly Challenges Gender and Sexuality

Mulan sets a framework for strong female characters whose agency is never questioned and who prove themselves through femininity, masculinity and ingenuity. My full essay was published on Link to Story

Tomm Moore, Writer/Director of Song of the Sea and The Secret of Kells

There is a certain magic to animation that allows filmmakers to bring our imagination to life. Even live action films depend on these techniques through CGI and other means to help us visualize fantastical versions of our own reality. This outlook drives Tomm Moore, one of the filmmakers behind The Secret of Kells (2009) and Song of the Sea (2014).
Movie Fail Link to Story

Genome-wide CRISPR Screen Identifies Regulators of MAPK as Suppressors of Liver Tumors in Mice

It has been a challenge to identify liver tumor suppressors or oncogenes due to the genetic heterogeneity of these tumors. We performed a genome-wide screen to identify suppressors of liver tumor formation in mice, using CRISPR-mediated genome editing.
Gastroenterology Link to Story


Søren Hough

I currently work as the head science writer at Desktop Genetics where I cover advances and applications of CRISPR technology (

I am also a freelance entertainment journalist. My work has been featured on key industry-centric websites including ( and (

I brought my experience as an editor and writer to The Massachusetts Daily Collegian ( one year later as I began working for the paper as a film and science correspondent. In the spring of 2013, I was hired as the editor of the film section of the paper for the fall of 2013.

I also started Movie Fail ( in January 2012, a site dedicated to multimedia reviews, op-eds, academic essays, and news articles about movies and the film industry.

In December 2013, I graduated from the Interdepartmental Program in Film Studies and Microbiology program at the University of Massachusetts Amherst.

The cover photo is a screen shot from Tete's short film, raintown.



  • Content Management
  • Film Journalism
  • Film Critique
  • Blogging
  • Editing
  • Final Cut Pro
  • Microbiology Research
  • Epigenetics Research
  • Molecular Biophysics Research
  • Social Media
  • Radio