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Søren Hough

Film Critic, Journalist, and Science Writer

London, UK

Søren Hough

Head science writer at Desktop Genetics. Freelance entertainment journalist. Founder/Editor-in-Chief at Movie Fail. Published at RogerEbert.com and ScottFeinberg.com. Former editor for film and television at the Massachusetts Daily Collegian.

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Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis

Oncogenic KRAS underlies 30–90% of lung, colon, and pancreatic cancers, but despite more than 30 y of research, clinical inhibitors of KRAS—and potential resistance mechanisms—remain elusive. Using CRISPR-mediated genome editing of oncogenic Kras, we show that some lung cancer cells can survive Kras knockout, indicating the existence of mechanisms that allow tumors to escape Kras oncogene addiction.
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Cell-Based Therapy for Disease Using CRISPR

CRISPR has accelerated basic research and therapeutic development. Its modular nature means it can be adapted to study and potentially treat nearly any genetic disease, including major killers like cancer and sickle cell anemia. The potential for CRISPR to transform medicine with highly precise, potentially one-off treatment options has given hope to those suffering from chronic and debilitating illness.
DESKGEN.com Link to Story
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Guide Picker is a comprehensive design tool for visualizing and selecting guides for CRISPR experiments

Guide Picker (https://www.deskgen.com/guide-picker/) serves as a meta tool for designing CRISPR experiments by presenting ten different guide RNA scoring functions in one simple graphical interface. It allows investigators to simultaneously visualize and sort through every guide targeting the protein-coding regions of any mouse or human gene.
BMC Bioinformatics Link to Story
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How Disney's "Mulan" Brazenly Challenges Gender and Sexuality

Mulan sets a framework for strong female characters whose agency is never questioned and who prove themselves through femininity, masculinity and ingenuity. My full essay was published on RogerEbert.com.
RogerEbert.com Link to Story
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Tomm Moore, Writer/Director of Song of the Sea and The Secret of Kells

There is a certain magic to animation that allows filmmakers to bring our imagination to life. Even live action films depend on these techniques through CGI and other means to help us visualize fantastical versions of our own reality. This outlook drives Tomm Moore, one of the filmmakers behind The Secret of Kells (2009) and Song of the Sea (2014).
Movie Fail Link to Story
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Genome-wide CRISPR Screen Identifies Regulators of MAPK as Suppressors of Liver Tumors in Mice

It has been a challenge to identify liver tumor suppressors or oncogenes due to the genetic heterogeneity of these tumors. We performed a genome-wide screen to identify suppressors of liver tumor formation in mice, using CRISPR-mediated genome editing.
Gastroenterology Link to Story
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The Magic of MAGI: Douglas Trumbull’s Quest to Explore a “New Planet of Cinematic Potential”

It began with something Stanley Kubrick once said. With "2001: A Space Odyssey," he felt he owed the audience an experience. He wanted to use Cinerama to show people what it was like to fly through space. This was ambitious for 1968, but it worked. The film has certainly stood the test of time, due in no small part to special effects provided by Douglas Trumbull, Wally Veevers, Con Pederson and Tom Howard.
RogerEbert.com Link to Story
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Desktop Genetics

Desktop Genetics is a bioinformatics company building a gene-editing platform for personalized medicine. The company works with scientists around the world to design and execute state-of-the-art clustered regularly interspaced short palindromic repeats (CRISPR) experiments.
Personalized Medicine Link to Story
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Zootopia with Ben and Søren

In this podcast, Søren and Ben discuss Disney’s animated film, Zootopia. Be sure to scroll down and read more about their respective opinions in more detail. As always, you can subscribe to our podcast feed using iTunes or by copying this link into your RSS reader. Alternatively, you can check out the episode online or download it here.
Movie Fail Link to Story
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Seymour, Lloyd Garrison

Lloyd Garrison Seymour was a civil war soldier, Republican activist, and estate owner who lived during the 19th century in Hartford, Connecticut. My article on Lloyd Garrison Seymour was accepted by the "African American National Biography, a joint project of the W. E. B. Du Bois Institute for African and African American Research at Harvard University and Oxford University Press." ~ from the W. E. B. Dubois Institute at Harvard University website.
Oxford/Harvard University Press Link to Story
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Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses

Our findings provide a strategy to model human liver diseases in mice and highlight the importance considering Cas9-specific immune responses in future translational studies involving in vivo delivery of CRISPR/Cas9.
Human Gene Therapy Link to Story
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On Seeing "Life Itself" at a Special Advance Screening

Red carpet, press wall, hors d'oeuvres. This was it, my first real film event.
RogerEbert.com Link to Story

About

Søren Hough

I currently work as the head science writer at Desktop Genetics where I cover advances and applications of CRISPR technology (https://www.deskgen.com/landing/resources).

I am also a freelance entertainment journalist. My work has been featured on key industry-centric websites including RogerEbert.com (www.rogerebert.com/interviews/the-magic-of-magi-douglas-trumbulls-quest-to-explore-a-new-planet-of-cinematic-potential) and ScottFeinberg.com (http://scottfeinberg.com/author/soren-hough).

I brought my experience as an editor and writer to The Massachusetts Daily Collegian (http://dailycollegian.com/author/soren-hough) one year later as I began working for the paper as a film and science correspondent. In the spring of 2013, I was hired as the editor of the film section of the paper for the fall of 2013.

I also started Movie Fail (http://moviefail.com) in January 2012, a site dedicated to multimedia reviews, op-eds, academic essays, and news articles about movies and the film industry.

In December 2013, I graduated from the Interdepartmental Program in Film Studies and Microbiology program at the University of Massachusetts Amherst.

The cover photo is a screen shot from Tete's short film, raintown.

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moviefail.com

Skills

  • CRISPR
  • Content Management
  • Film Journalism
  • Film Critique
  • Blogging
  • Editing
  • Final Cut Pro
  • Microbiology Research
  • Epigenetics Research
  • Molecular Biophysics Research
  • Social Media
  • Radio