Søren Hough

Cancer Biologist, Journalist, and Science Writer

London, UK

Søren Hough

Cancer Biologist. Science Writer. Freelance journalist/editor. Founder/Editor-in-Chief at Movie Fail. Published at


Strategies for Improving CRISPR Specificity

Modifying nucleases and guide RNAs may reduce the off-target effect. Link to Story

Expanding Genome Editing Beyond Traditional CRISPR Nucleases

How Cas9 orthologs and other nucleases open new doors for basic and translational research. Link to Story

CRISPR Base Editing for Precise Genome Edits

Base editing precisely substitutes nucleotides and introduces point mutations for validation of clinically-relevant variants, and on a large scale, allows for the design of forward screens. Link to Story

The Future of CRISPR Applications in the Lab, the Clinic and Society.

CRISPR (clustered regularly interspaced short palindromic repeats) has emerged as one of the premiere biological tools of the century. Even more so than older genome editing techniques such as TALENs and ZFNs, CRISPR provides speed and ease-of-use heretofore unheard of in agriculture, the environment and human health.
Advances in Experimental Medicine and Biology, Springer Link to Story

Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis

Oncogenic KRAS underlies 30–90% of lung, colon, and pancreatic cancers, but despite more than 30 y of research, clinical inhibitors of KRAS—and potential resistance mechanisms—remain elusive. Using CRISPR-mediated genome editing of oncogenic Kras, we show that some lung cancer cells can survive Kras knockout, indicating the existence of mechanisms that allow tumors to escape Kras oncogene addiction.

Cell-Based Therapy for Disease Using CRISPR

CRISPR has accelerated basic research and therapeutic development. Its modular nature means it can be adapted to study and potentially treat nearly any genetic disease, including major killers like cancer and sickle cell anemia. The potential for CRISPR to transform medicine with highly precise, potentially one-off treatment options has given hope to those suffering from chronic and debilitating illness. Link to Story

Guide Picker is a comprehensive design tool for visualizing and selecting guides for CRISPR experiments

Guide Picker ( serves as a meta tool for designing CRISPR experiments by presenting ten different guide RNA scoring functions in one simple graphical interface. It allows investigators to simultaneously visualize and sort through every guide targeting the protein-coding regions of any mouse or human gene.
BMC Bioinformatics Link to Story

Genome-wide CRISPR Screen Identifies Regulators of MAPK as Suppressors of Liver Tumors in Mice

It has been a challenge to identify liver tumor suppressors or oncogenes due to the genetic heterogeneity of these tumors. We performed a genome-wide screen to identify suppressors of liver tumor formation in mice, using CRISPR-mediated genome editing.
Gastroenterology Link to Story

Desktop Genetics

Desktop Genetics is a bioinformatics company building a gene-editing platform for personalized medicine. The company works with scientists around the world to design and execute state-of-the-art clustered regularly interspaced short palindromic repeats (CRISPR) experiments.
Personalized Medicine Link to Story

Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses

Our findings provide a strategy to model human liver diseases in mice and highlight the importance considering Cas9-specific immune responses in future translational studies involving in vivo delivery of CRISPR/Cas9.
Human Gene Therapy Link to Story

Sequencing Options for CRISPR Genotyping

This post was contributed by guest blogger Søren Hough, the Head Science Writer at Desktop Genetics. One of the most important steps in the CRISPR experimental process is validating edits. Regardless of which CRISPR genome editing system you use, there remains a chance that the observed phenotype was caused by an off-target mutation and not an edit in the target gene.
Addgene Link to Story

CRISPR Applications in Oncology Research

This resource was written with Dr. Leigh Brody and is aimed at cancer researchers and clinicians who aren't necessarily gene editing specialists. The piece describes what CRISPR is and its caveats as a gene editing tool, how it's been used to study and treat disease so far how it can be used to in relation to cancer. Link to Story


Søren Hough

I currently work as the head science writer at Desktop Genetics where I cover advances and applications of CRISPR technology (

I am also a freelance entertainment journalist. My work has been featured on key industry-centric websites including ( and (

I brought my experience as an editor and writer to The Massachusetts Daily Collegian ( one year later as I began working for the paper as a film and science correspondent. In the spring of 2013, I was hired as the editor of the film section of the paper for the fall of 2013.

I also started Movie Fail ( in January 2012, a site dedicated to multimedia reviews, op-eds, academic essays, and news articles about movies and the film industry.

In December 2013, I graduated from the Interdepartmental Program in Film Studies and Microbiology program at the University of Massachusetts Amherst.

The cover photo is a screen shot from Tete's short film, raintown.



  • Film Journalism
  • Film Critique
  • Blogging
  • Editing
  • Final Cut Pro
  • Microbiology Research
  • Epigenetics Research
  • Molecular Biophysics Research
  • Social Media
  • Radio
  • Content Management